Why We Hate OspA: Shortest Explainer Ever

OspA is one of the outer surface proteins of the Lyme spirochete. There are many of them, labeled A, B, C, etc. So A is pretty important, being the first one. The problem with OspA is that it is a TLR2 agonist. Most TLR2 agonists are fungal, so we refer to them as fungal antigens or fungal-like antigens. Scroll down to the list, here: http://en.m.wikipedia.org/wiki/TLR2.

Fungal antigens ‘tolerize’ the immune cells, so they no longer fight off other fungal antigens. (1, 2) They can also cross-tolerize you to other types of infections. (3) The immune system becomes suppressed and multiple herpesviruses (EBV, CMV, HHV-6 to name a few) can be reactivated. (4) This is known as fungal-viral synergy. Due to the immunosuppression, you may not even produce antibodies to these herpesviruses. You also become susceptible to all kinds of opportunistic infections. The NIH refers to this model as Post…

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About The Other Side Of The Stretcher

Nurse turned patient, but not by choice. I was became a Registered Nurse in 1985 when I was 21 years old. That career was cut short the end of 1994 when I was unable to work anymore because of the illness M.E. or Myalgic Encephalomyelitis. I have 3 adult children including twins, A daughter and 2 sons. View all posts by The Other Side Of The Stretcher

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